Inside Front Cover: Is a Malleable Active Site Loop the Key to High Substrate Promiscuity? Hybrid, Biocatalytic Route to Structurally Diverse Taxoid Side Chains with Remarkable Dual Stereocontrol (Angew. Chem. Int. Ed. 36/2025)
In their Research Article (e202510889), Berkowitz, Wilson, Grubmueller and co-workers describe the malleable structure of CaADH (Clostridium acetobutylicum alcohol dehydrogenase) and its panoply of loop conformers (top). They deploy CaADH for a dynamic reductive kinetic resolution (DYRKR) entry into new side chains for the Taxotere family of chemotherapeutics. The middle image shows an X-ray crystal structure of a key enzymatic product and Taxotere building block with the proper stereochemistry. Artistic Credit: Ewa Kijowska-Stroes.
Authors
- Joseph D. Ferrara (ORCID: https://orcid.org/0000-0001-8534-642X)
- Wei Niu (ORCID: https://orcid.org/0000-0003-3826-1276)
- N. N. Bhuvan Kumar (ORCID: https://orcid.org/0000-0003-3723-6642)
- Victor W. Day
- Mark A. Wilson (ORCID: https://orcid.org/0000-0001-6317-900X)
- David B. Berkowitz (ORCID: https://orcid.org/0000-0001-7550-0112)
- Helmut Grubmüller (ORCID: https://orcid.org/0000-0002-3270-3144)
- Jared L. Hass (ORCID: https://orcid.org/0000-0002-0903-6291)
- Gaurav P. Kudalkar
- Akihito Yamano
- Lee M. Daniels
- Shô Itô (ORCID: https://orcid.org/0000-0002-7439-7050)
- Peter Madzelan
- Florian Leidner (ORCID: https://orcid.org/0000-0002-0048-889X)
- Douglas R. Powell (ORCID: https://orcid.org/0000-0001-7133-468X)
- Pierre Le Maguerès
Institutions
- University of Nebraska–Lincoln (US)
- University of Kansas (US)
- Rigaku (Japan) (JP)
- Max Planck Institute for Biophysical Chemistry (DE)
- University of Oklahoma (US)
Publication Details
- Journal
- Angewandte Chemie International Edition
- Published
- 2025-08-21
- DOI
- https://doi.org/10.1002/anie.202517791
- Primary Topic
- Cancer Treatment and Pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 0.00