CLINICAL AND IMMUNOLOGICAL STATUS INDICATORS IN THE CALVES' DIARRHEA TREATMENT WITH A PHYTOPROBIOTIC AGENT

The aim of the study is to conduct a comparative analysis of clinical and some immuno-biochemical parameters when using a complex phytoprobiotic agent to treat diarrhea in calves. For the experiment, two groups of newborn calves with signs of diarrhea were formed on a farm in the Zabaikalsky Region, with 10 animals in each (n = 20). From the second day of life, the calves of the experimental group were given the developed phytoprobiotic agent in the form of a solution, which included: bergenia radix root, rose hips (Surrexit coxis), chamomile flower decoction (Pyrethri flores), eleutherococcus rhizome (Rhizomede Siberian ginseng), and the probiotic Bacillus subtillis VKPM B-10641 at a dose of 1.5 ml/kg of live weight twice a day at 12-hour intervals; The control group of animals was given a solution of Bacillus subtillis VKPM B-10641 of at least 1 · 106 CFU of live bacterial spores at a dose of 3 ml/kg once a day for 10 days. Using generally accepted methods of clinical and laboratory analysis, the calves of the experimental group after 10 days of therapy recorded: normalization of clinical and hematological parameters, an increase in the level of total protein by 32.6%, an increase in albumin by 5.4 %. In animals of the control group, probably as a result of dehydration of the body, the albumin level was reduced by 4.2 %. An increase in globulins in the blood serum of young animals was observed by 12.8 and 14.7%, respectively (P ˂ 0.05). The albumin-globulin ratio in the experimental group corresponded to the normal background (1.0-1.2 units). Bactericidal and lysozyme activity of blood serum increased by 8.5 and 36.6 %, respectively (P ˂ 0.01). The complex phytoprobiotic can be recommended for oral therapy both for newborn calves and in their post-milk period as an astringent, anti-inflammatory and increasing non-specific resistance of the body agent, thereby reducing the use of synthetic drugs.