Daikenchuto improves methotrexate-induced chronic small intestinal mucositis by promoting angiogenesis
DKT exerts protective effects against MTX-induced CIM by enhancing angiogenesis, promoting epithelial regeneration, and restoring mucosal barrier function. These findings suggest DKT as a promising adjunctive therapy for managing chronic intestinal toxicity induced by chemotherapy.
Authors
- Sachiko Mogami (ORCID: https://orcid.org/0000-0001-7914-4928)
- Susumu Eguchi (ORCID: https://orcid.org/0000-0002-7876-0152)
- Akihiko Soyama (ORCID: https://orcid.org/0000-0003-2932-4300)
- Kengo Kanetaka (ORCID: https://orcid.org/0000-0002-1620-7044)
- Toshiyuki Adachi (ORCID: https://orcid.org/0000-0001-6055-9808)
- Peilin Li (ORCID: https://orcid.org/0000-0002-9136-0882)
- Daisuke Miyamoto (ORCID: https://orcid.org/0000-0003-0367-9904)
- Daichi Sadatomi
- Weili Gu
- Yusuke Inoue (ORCID: https://orcid.org/0000-0001-8075-0597)
- Tomohiko Adachi (ORCID: https://orcid.org/0000-0001-7025-6173)
Institutions
- Tsumura Research Institute (Japan) (JP)
- Guangzhou First People's Hospital (CN)
- Nagasaki University (JP)
- South China University of Technology (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-08-21
- DOI
- https://doi.org/10.3389/fphar.2025.1623726
- Primary Topic
- Oral health in cancer treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00