A <scp>2B</scp> Protein‐Derived Peptide Effectively Inhibits Coxsackievirus <scp>B3</scp> Infection

The nonstructural 2B protein of coxsackievirus B (CVB) is a transmembrane protein that forms a hydrophilic tetramer viroporin on the cellular membrane structures. 2B plays a key role in the replication of CVB. We hypothesized that blocking the polymerization of 2B may interfere with CVB replication. In this study, a 2B-derived peptide 2B<sub>37-50</sub> demonstrated potent anti-CVB3 activity in vitro. A Tat-fused 2B<sub>37-50</sub> (Tat-2B<sub>37-50</sub>) showed significant inhibitory effects on the viral protein expression, RNA synthesis, and replication of CVB3. Tat-2B<sub>37-50</sub> treatment elicited a strong in vivo protective efficacy for the myocardial infection caused by CVB3. Tat-2B<sub>37-50</sub> was also effective against the infection of enterovirus A71 and coxsackievirus A16. Taken together, Tat-2B<sub>37-50</sub> has the potential to be a novel peptide drug for the treatment of CVB infection.

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Publication Details

Journal
The FASEB Journal
Published
2025-08-21
DOI
https://doi.org/10.1096/fj.202500209r
Citations
1
Primary Topic
Viral Infections and Immunology Research
Type
article
Field-Weighted Citation Impact
1.39

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article

A 2B Protein‐Derived Peptide Effectively Inhibits Coxsackievirus B3 Infection

Chen Yuan, Zhaohua Zhong, Lexun Lin, Li‐Lian Yuan et al.
1 citations
The FASEB Journal
Viral Infections and Immunology Research
1.39
article

A 2B Protein‐Derived Peptide Effectively Inhibits Coxsackievirus B3 Infection

Chen Yuan, Zhaohua Zhong, Lexun Lin, Li‐Lian Yuan, Zhaozhu Li, Jingying Zhou, Jinchang Liu, Wenran Zhao, Guangtian Wang, Qingbo Cui, Yao Wang, Yang Chen, Siyu Li, Xiyan Yang, Ruping Dong, Jingqi Wu, Yan Wang
article en
1 citations

Abstract

The nonstructural 2B protein of coxsackievirus B (CVB) is a transmembrane protein that forms a hydrophilic tetramer viroporin on the cellular membrane structures. 2B plays a key role in the replication of CVB. We hypothesized that blocking the polymerization of 2B may interfere with CVB replication. In this study, a 2B-derived peptide 2B<sub>37-50</sub> demonstrated potent anti-CVB3 activity in vitro. A Tat-fused 2B<sub>37-50</sub> (Tat-2B<sub>37-50</sub>) showed significant inhibitory effects on the viral protein expression, RNA synthesis, and replication of CVB3. Tat-2B<sub>37-50</sub> treatment elicited a strong in vivo protective efficacy for the myocardial infection caused by CVB3. Tat-2B<sub>37-50</sub> was also effective against the infection of enterovirus A71 and coxsackievirus A16. Taken together, Tat-2B<sub>37-50</sub> has the potential to be a novel peptide drug for the treatment of CVB infection.

The FASEB JournalVol. 39(16)
Harbin Medical University (CN), Third Affiliated Hospital of Harbin Medical University (CN), Second Affiliated Hospital of Harbin Medical University (CN), First Affiliated Hospital of Harbin Medical University (CN)
National Natural Science Foundation of China
Openalex Percentile: Top 16%
Viral Infections and Immunology Research
1.39
DOISourceOpenAlex
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