The NEAT1/miR-124-3p/CCL2 axis in chronic kidney disease progression: integrated bioinformatics analysis and experimental validation
EGF,VCAN, CXCL1, MMP7, and particularly CCL2 are potential CKDbiomarkers/therapeutic targets. The NEAT1/miR-124-3p/CCL2 axis is a keyregulatory pathway in CKD. Key limitations include the moderate sample sizes inbioinformatics and clinical cohorts.
Authors
- Kang Yang (ORCID: https://orcid.org/0000-0001-5037-8771)
- Jianfeng Wang (ORCID: https://orcid.org/0000-0002-5990-8166)
- Xu Chen (ORCID: https://orcid.org/0000-0002-0260-8832)
- Xixi Wang (ORCID: https://orcid.org/0000-0003-4633-2345)
- Linqi Zhang (ORCID: https://orcid.org/0000-0002-0607-6300)
- Yaoxian Wang (ORCID: https://orcid.org/0000-0002-3658-8200)
- Guanting Chen (ORCID: https://orcid.org/0000-0003-1354-5192)
Institutions
- First Affiliated Hospital of Henan University (CN)
Publication Details
- Journal
- Epigenomics
- Published
- 2025-08-21
- DOI
- https://doi.org/10.1080/17501911.2025.2548762
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China