Silver Nanoparticles and Houttuynin Sodium‐Based Fibrous Poly(L‐lactide‐co‐glycolide)/Gelatin‐Based Dressings for Infectious Wound Healing

Bacterial infections present debilitating challenges for skin repair, particularly in managing complex microbial colonization and persistent inflammation that delay healing. To address this clinical gap, a dual-functional electrospun dressing (PG@AgH) was developed by incorporating silver nanoparticles (Ag NPs) and houttuynin sodium (H) into poly(L-lactide-co-glycolide)/gelatin (PG) fibers. Compared to conventional dual-agent systems, PG@AgH achieves spatiotemporally controlled release. Ag NPs provide rapid antibacterial action against multidrug-resistant pathogens (e.g., S. aureus, E. coli), while H sustains anti-inflammatory modulation through macrophage polarization regulation. In vitro studies confirmed cytocompatibility and broad-spectrum antimicrobial efficacy against bacterial (S. aureus, E. coli) and fungal (C. albicans) strains. Moreover, the PG@AgH dressings promoted rapid wound closure, enhanced collagen deposition, and reduced bacterial load at the wound site in S. aureus-infected full-thickness excisional defect model in rats. Taken together, this multifunctional approach overcomes the limitations of single-mechanism dressings, offering a clinically translatable strategy for infectious wound management.