Palladium-Catalyzed Cycloisomerization of Bicyclobutyl (BCB) Amides to Access Polycyclic Quinolinones
A novel palladium-catalyzed cycloisomerization of bicyclobutyl amides has been developed for the expedited construction of polycyclic quinolinone skeletons. The reaction proceeded well to furnish a variety of tetracyclic quinolinone derivatives in good yields. Additionally, scale-up reactions and derivatization of tetracyclic quinolinones were demonstrated as well.
Authors
- Linqi Wang (ORCID: https://orcid.org/0000-0002-5243-341X)
- Jun Ying (ORCID: https://orcid.org/0000-0002-9578-2863)
- Yan Cao (ORCID: https://orcid.org/0000-0001-7866-1640)
- Jianwei Wang
Institutions
- Zhejiang Sci-Tech University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-08-20
- DOI
- https://doi.org/10.1021/acs.orglett.5c03075
- Citations
- 5
- Primary Topic
- Cyclopropane Reaction Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 4.68
Funders
- National Natural Science Foundation of China
- Zhejiang Sci-Tech University