Clade I mpox vaccination: strategies for deployment and evaluation
Clade I mpox continues to spread in Central Africa with no sign of abating,1 however very few doses of vaccine have been deployed. Mpox vaccination strategies using either of the licenced vaccines, MVA-BN and LC16m8, are being drawn up across 17 African countries and vaccination has begun in the Democratic Republic of Congo (DRC), Rwanda and Nigeria.2 Clinical studies during the rollout could deliver much-needed data about the effectiveness of the vaccine against clade I mpox. Choosing the right study design is fundamental.
Authors
- M. Grabowski (ORCID: https://orcid.org/0000-0002-8072-4919)
- Chris Wymant (ORCID: https://orcid.org/0000-0002-9847-8226)
- Marc Lipsitch (ORCID: https://orcid.org/0000-0003-1504-9213)
- Christophe Fraser (ORCID: https://orcid.org/0000-0003-2399-9657)
- Francesco Di Lauro (ORCID: https://orcid.org/0000-0002-3973-017X)
- Ronald Moses Galiwango (ORCID: https://orcid.org/0000-0003-3702-5722)
- Robert Hinch (ORCID: https://orcid.org/0000-0003-3169-698X)
- Jasmina Panovska‐Griffiths (ORCID: https://orcid.org/0000-0002-7720-1121)
- Lucie Abeler‐Dörner (ORCID: https://orcid.org/0000-0003-3662-4192)
- Deogratius Ssemwanga (ORCID: https://orcid.org/0000-0001-9675-4234)
- Luca Ferretti (ORCID: https://orcid.org/0000-0001-7578-7301)
- Jake Dunning (ORCID: https://orcid.org/0000-0002-4035-4562)
- Caitlin Pley (ORCID: https://orcid.org/0000-0003-2611-1262)
- Joseph Kagaayi (ORCID: https://orcid.org/0000-0003-4101-3038)
- Pontiano Kaleebu
- James A. Hay (ORCID: https://orcid.org/0000-0002-1998-1844)
Institutions
- Harvard University (US)
- University of Oxford (GB)
- Rakai Health Sciences Program (UG)
- Jenner Institute (GB)
- Makerere University (UG)
- Uganda Virus Research Institute (UG)
Publication Details
- Journal
- EBioMedicine
- Published
- 2025-08-20
- DOI
- https://doi.org/10.1016/j.ebiom.2025.105890
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Coalition for Epidemic Preparedness Innovations
- University of Oxford
- Precursory Research for Embryonic Science and Technology