Wild-Type Transthyretin Amyloidosis in the Kidneys
Wild-type transthyretin (ATTRwt) amyloidosis typically presents with restrictive cardiomyopathy. Kidney involvement is exceedingly rare. We report to our knowledge the first antemortem diagnosis of ATTRwt amyloidosis with kidney vasculature deposition in a patient presenting with progressive kidney failure. Notably, technetium-99m pyrophosphate scintigraphy showed no myocardial uptake. This case expands the known spectrum of organ involvement in ATTRwt amyloidosis and underscores the need to consider extracardiac manifestations in its diagnosis.
Authors
- Tatiana Prokaeva (ORCID: https://orcid.org/0000-0002-0790-602X)
- Vaishali Sanchorawala (ORCID: https://orcid.org/0000-0002-6307-2445)
- Eric Burks (ORCID: https://orcid.org/0000-0002-3122-2875)
- Deepa M. Gopal (ORCID: https://orcid.org/0000-0003-3534-9360)
- Tracy Joshi (ORCID: https://orcid.org/0000-0003-4048-6271)
- Ellen D. McPhail (ORCID: https://orcid.org/0000-0001-6918-3376)
- Andrew Staron (ORCID: https://orcid.org/0000-0003-1638-4873)
- Surendra Dasari (ORCID: https://orcid.org/0000-0002-7972-3556)
- Ashish Verma (ORCID: https://orcid.org/0000-0001-9497-6327)
- Hui Chen (ORCID: https://orcid.org/0000-0001-5704-5486)
Institutions
- Boston University (US)
- Mayo Clinic (US)
- Amyloidosis Foundation (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- JACC Case Reports
- Published
- 2025-08-20
- DOI
- https://doi.org/10.1016/j.jaccas.2025.105132
- Primary Topic
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00