Decreased Mitochondrial DNA Integrity and Elevated Inflammatory Markers in Late-Life Depression: A Longitudinal Study
Increased ccf-mtDNA instability may heighten vulnerability to emotional dysregulation and medical burden in individuals with LLD. Further research is needed to validate our findings and elucidate the mechanisms that connect mitochondrial instability and inflammation in LLD.
Authors
- James Kennedy (ORCID: https://orcid.org/0000-0003-2760-8318)
- Breno Satler Diniz (ORCID: https://orcid.org/0000-0003-0653-1905)
- Lloyd Balbuena (ORCID: https://orcid.org/0000-0002-3745-5426)
- Parvaiz Ahmad (ORCID: https://orcid.org/0000-0003-2734-4180)
- Ana Paula Mendes‐Silva (ORCID: https://orcid.org/0000-0002-0636-7239)
- Tarek K. Rajji (ORCID: https://orcid.org/0000-0002-8324-2560)
- Érica Leandro Marciano Vieira (ORCID: https://orcid.org/0000-0002-4147-5614)
- Vanessa F. Gonçalves (ORCID: https://orcid.org/0000-0001-5619-8755)
- Yuliya S. Nikolova (ORCID: https://orcid.org/0000-0001-5144-3723)
- Ana Paula Costa (ORCID: https://orcid.org/0000-0002-4632-038X)
Institutions
- Centre for Addiction and Mental Health (CA)
- University of Pittsburgh (US)
- University of Toronto (CA)
- University of Saskatchewan (CA)
- UConn Health (US)
Publication Details
- Journal
- Biological Psychiatry Global Open Science
- Published
- 2025-08-20
- DOI
- https://doi.org/10.1016/j.bpsgos.2025.100598
- Citations
- 1
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.58