Anti‐ <scp>IL</scp> ‐5 Vaccination Dampens Allergen‐Specific <scp>IgE</scp> Levels and Modulates <scp>IL</scp> ‐4 and <scp>IL</scp> ‐5 Th2 Cytokines in Skin Allergy of Mice and Horses
IL-5 vaccination significantly decreased allergen-specific IgE in both the murine skin allergy model and horses with naturally occurring allergic skin disease, as well as alleviated clinical signs of the diseases. We suggest that the IL-5 depletion may modulate the IL-4 levels originating from non-T cell sources. This is the first study showing that an IL-5 vaccination leads to a decrease in allergen-specific IgE levels, potentially suggesting its use in prophylactic settings for high-risk patients.
Authors
- Thomas M. Kündig (ORCID: https://orcid.org/0000-0003-3863-8766)
- Stanislav Pantelyushin (ORCID: https://orcid.org/0000-0002-3490-3860)
- Katharina Birkmann (ORCID: https://orcid.org/0000-0002-1142-2132)
- Fabia Canonica (ORCID: https://orcid.org/0000-0003-4324-3961)
- Fadi Jebbawi (ORCID: https://orcid.org/0000-0001-6055-6818)
- Pål Johansen (ORCID: https://orcid.org/0000-0002-5055-6299)
- Juwela Lam
- Tanya Rhiner
- Florian Olomski
- Antonia Fettelschoss‐Gabriel (ORCID: https://orcid.org/0000-0002-6189-172X)
- Nina Waldern
- Victoria Inversini (ORCID: https://orcid.org/0009-0001-1451-6054)
- Giulia Keller
Institutions
- University of Zurich (CH)
- University Hospital of Zurich (CH)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Allergy
- Published
- 2025-08-21
- DOI
- https://doi.org/10.1111/all.70020
- Citations
- 2
- Primary Topic
- Allergic Rhinitis and Sensitization
- Type
- article
- Field-Weighted Citation Impact
- 3.24
Funders
- Colorado Humanities
- Knowles Teacher Initiative
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Kommission für Technologie und Innovation