Acute cannabidiol (CBD), tetrahydrocannabinol (THC) and their mixture (THC:CBD) exert differential effects on brain activity and blood flow in rats: A translational neuroimaging study
In conclusion, we show that THC and CBD induce distinct neurophysiological profiles in rats, with THC increasing both connectivity and perfusion, moderated by CBD when combined. These findings corroborate existing knowledge about the effects of cannabinoids on the brain, while also supporting the potential of preclinical functional neuroimaging to delineate cannabinoid-induced endophenotypes, offering insights for therapeutic development.
Authors
- Tanya Andrews
- Benjamin J. Whalley
- Donna-Michelle Smith
- Michelle Kokkinou (ORCID: https://orcid.org/0000-0001-7014-2264)
- Diana Cash (ORCID: https://orcid.org/0000-0001-5021-1234)
- Andrew C. McCreary (ORCID: https://orcid.org/0000-0003-3614-9117)
- Royston A. Gray
- Steven Williams (ORCID: https://orcid.org/0000-0003-4299-1941)
- Loreto Rojo Gonzalez
- Sally Loomis
- Jennifer Li (ORCID: https://orcid.org/0000-0003-0186-8613)
- Volker Knappertz
- Eilidh MacNicol (ORCID: https://orcid.org/0000-0003-3715-7012)
- Michel Mesquita (ORCID: https://orcid.org/0000-0002-5594-5605)
- Camilla Simmons (ORCID: https://orcid.org/0000-0002-8561-4241)
- David Virley
- Eugene Kim (ORCID: https://orcid.org/0000-0003-0066-7051)
- Maria Elisa Serrano Navacerrada (ORCID: https://orcid.org/0000-0003-0880-6183)
Institutions
- King's College London (GB)
- Systems, Applications & Products in Data Processing (United Kingdom) (GB)
- ABS Consulting (United States) (US)
- Jazz Pharmaceuticals (France) (FR)
- Heinrich Heine University Düsseldorf (DE)
- University of Reading (GB)
- GW Pharmaceuticals (United Kingdom) (GB)
Publication Details
- Journal
- Journal of Psychopharmacology
- Published
- 2025-08-21
- DOI
- https://doi.org/10.1177/02698811251360745
- Citations
- 1
- Primary Topic
- Cannabis and Cannabinoid Research
- Type
- article
- Field-Weighted Citation Impact
- 1.39