Figure 6 from Direct Co-Targeting of Bcl-xL and Mcl-1 Exhibits Synergistic Effects in AR-V7–Expressing CRPC Models
<p>XZ739 in combination with S63845 has synergistic antitumor effects in CRPC cell lines. <b>A</b> to <b>I,</b> CellTiter-Glo viability data from 2D cultures of LNCaP95, VCaP-CR, and 22Rv1 cell lines. Cell viability data for the dual treatment (<b>A–C</b>) were generated by CellTiter-Glo. Dose–response matrices (<b>D–F</b>) and Bliss synergy plots (<b>G–I</b>) were created using the SynergyFinder+ R package. <b>J</b> to <b>M,</b> 3D spheroid model and cell viability of LNCaP95 (<b>J</b> and <b>K</b>) and 22Rv1 cells (<b>L</b> and <b>M</b>). Data are presented as mean ± SD. **, <i>P</i> < 0.01; ****, <i>P</i> < 0.0001. All experiments were completed in triplicate. Spheroid images are representative of three replicates.</p>
Authors
- Kelli M. Wilson (ORCID: https://orcid.org/0000-0003-2636-2766)
- Erin Beck
- Andres F. Leon (ORCID: https://orcid.org/0009-0003-3187-6582)
- Craig J. Thomas (ORCID: https://orcid.org/0000-0001-9386-9001)
- Kinjal Bhadresha
- Xiaohu Zhang (ORCID: https://orcid.org/0000-0002-5872-4656)
- Keith Thomas Schmidt (ORCID: https://orcid.org/0009-0008-0285-0216)
- Jessica D. Kindrick (ORCID: https://orcid.org/0000-0003-1519-9721)
- Adam G. Sowalsky (ORCID: https://orcid.org/0000-0003-2760-1853)
- Carleen Klumpp‐Thomas (ORCID: https://orcid.org/0000-0002-6646-6132)
- Michele Ceribelli (ORCID: https://orcid.org/0000-0001-9857-9521)
- Erica L. Beatson (ORCID: https://orcid.org/0000-0003-4517-906X)
- Crystal McKnight (ORCID: https://orcid.org/0009-0007-6554-5772)
- Giulia C. Napoli (ORCID: https://orcid.org/0009-0006-7354-8693)
- Douglas K. Price (ORCID: https://orcid.org/0000-0002-7051-7510)
- William D. Figg (ORCID: https://orcid.org/0000-0003-2428-5613)
- Emily N. Risdon (ORCID: https://orcid.org/0000-0002-5888-8634)
- JuanJuan Yin (ORCID: https://orcid.org/0000-0001-6739-5463)
- Cindy H. Chau (ORCID: https://orcid.org/0000-0002-6928-3833)
- Benjamin C. Brim (ORCID: https://orcid.org/0000-0002-6713-3292)
Publication Details
- Published
- 2025-08-21
- DOI
- https://doi.org/10.1158/2767-9764.29957552
- Primary Topic
- Cell Adhesion Molecules Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00