Glucose-6-phosphate dehydrogenase deficiency induced hemolytic anemia and methemoglobinemia: a case report in a 7 -year-old female patient

When G6PDH deficiency and methemoglobinemia coexist, a prompt diagnosis is essential. The administration of methylene blue, therapy of choice for the treatment of methemoglobinemia, in fact, may cause a worsening of hemolytic crises in patients affected by G6PDH deficiency. Considering our patient's clinical features, not clearly evocative of G6PDH deficiency, this case represented a challenge for both diagnosis and treatment, reminding to always consider G6PDH deficiency in case of hemolytic anemia associated with methemoglobinemia.