Evaluation of myocardial structure and function in hypertrophic obstructive cardiomyopathy via cardiovascular magnetic resonance: regional distribution and sex differences

Mean WT emerged as the most robust structural determinant of myocardial strain impairment in patients with HOCM, surpassing other hypertrophic characteristics and fibrosis surrogates. Notably, functional deterioration was most prominent in the apical regions and among female patients. These findings highlight the importance of incorporating sex-specific and region-specific hypertrophic patterns into individualized diagnostic and therapeutic strategies to improve clinical outcomes.