Synthesis and Reaction of Pentafluorosulfanyl Chloride (<scp>SF₅Cl</scp>)

Comprehensive Summary The pentafluorosulfanyl (SF 5 ) group, characterized by its high electronegativity, lipophilicity and unique octahedral geometry, has the potential to modify the physicochemical properties of both pharmaceuticals and agrochemicals. Recently, pentafluorosulfanyl‐containing compounds have garnered increasing attention, and big progress has been made in the development of novel synthetic strategies for these compounds. Central to these advancements is the exploration of synthesis and novel reaction of radical pentafluorosulfanylation reagents. This account provides an overview of the gas‐reagent‐free practical synthesis and new reaction of pentafluorosulfanyl chloride (SF 5 Cl) developed by our group. Key Scientists of SF 5 Chemistry A partial list of the key scientists’ main contributions to the development of pentafluorosulfanyl chemistry