Early use of albumin may increase the risk of sepsis-associated acute kidney injury in sepsis patients: a target trial emulation
Early albumin administration may increase the risk of SA-AKI in sepsis patients without conferring a short-term survival benefit. These results underscore the need for a rigorous risk-benefit assessment when incorporating albumin into sepsis resuscitation protocols and highlight the need for further clinical validation. However, it is important to exercise caution when interpreting the conclusions of this study, given its exploratory and preliminary nature.
Authors
- Wei‐Sheng Chen (ORCID: https://orcid.org/0000-0001-8672-180X)
- Jianguang Chen (ORCID: https://orcid.org/0000-0002-5789-4792)
- Zhongkai Qu
- Yu Wang (ORCID: https://orcid.org/0000-0003-1581-0818)
- Li Li (ORCID: https://orcid.org/0000-0002-9897-7818)
- Jun Lyu (ORCID: https://orcid.org/0000-0002-2237-8771)
- Shuna Li (ORCID: https://orcid.org/0000-0003-0301-5809)
- Xinya Li (ORCID: https://orcid.org/0000-0002-7539-8194)
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Jinan University (CN)
- Community Health Center (US)
- First Affiliated Hospital of Jinan University (CN)
Publication Details
- Journal
- Military Medical Research
- Published
- 2025-08-21
- DOI
- https://doi.org/10.1186/s40779-025-00641-z
- Citations
- 1
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- Massachusetts Institute of Technology