Influence of bioengineering and bioinformatics technologies on public health status

Objective: identify the most significant bioengineering and bioinformatics technologies aimed at preserving and strengthening the health of the population. Methodology for writing a review. The systematic review was performed on the PRISMA methodology applying the PubMed, eLibrary, Google Scholar, CyberLeninka databases. The search period was from 2006 to 2025. 50 sources were used to write the review. Conclusion. A review of scientific works suggests a significant potential of the development of bioengineering and bioinformatics technologies to improve population health. Analysis of studies focused on genome editing revealed the emergence of new technologies (CRISPR/Cas9, CAR-T) in the treatment of previously incurable and orphan diseases. Bioinformatics researches, related to the genome/clinic database (TCGA, GWAS), focus on the identifying of risk factors and predictors of human diseases. The modern tendency in regenerative medicine is aimed at the creating of the individual products for tissues and organs recovering (3D-printed models). They help to reduce the rehabilitation periods and return the patients to the working life. At the present, there are pressing issues of assessment the medical, economic and social effectiveness of presented here technologies. They can be integrated into healthcare system after justification of the organizational technologies.