Front Cover: Inhibition of the Clathrin Terminal Domain—Amphiphysin Protein–Protein Interaction. Probing the Pitstop 2 Aromatic Moiety (ChemMedChem 16/2025)
This image shows the crystal structure of the N-terminal domain of clathrin with the known binding sites colored. Site 1 is colored in yellow, and an expansion shows a stylized image of the predicted binding of a Pitstop 2 analogue compared to Pitstop 2 in binding site. The background shows a selection of the Pitstop 2 analogues described in the article in various colors. More details can be found in research article 10.1002/cmdc.202500321 by Adam McCluskey and co-workers.
Authors
- Phillip J. Robinson (ORCID: https://orcid.org/0000-0002-7878-0313)
- Volker Haucke (ORCID: https://orcid.org/0000-0003-3119-6993)
- Kate Prichard (ORCID: https://orcid.org/0000-0003-0458-5037)
- Ngoc Chau (ORCID: https://orcid.org/0000-0001-5507-0493)
- Adam McCluskey (ORCID: https://orcid.org/0000-0001-7125-863X)
- Marc Nazaré (ORCID: https://orcid.org/0000-0002-1602-2330)
- Mark J. Robertson (ORCID: https://orcid.org/0000-0002-2140-2717)
- André Horatscheck (ORCID: https://orcid.org/0000-0001-6485-6391)
- Martin Neuenschwander (ORCID: https://orcid.org/0000-0002-3114-7975)
- Jing Xue (ORCID: https://orcid.org/0009-0007-1062-2881)
- Uwe Fink
Institutions
- Children's Medical Research Institute (AU)
- Leibniz Association (DE)
- University of Newcastle Australia (AU)
Publication Details
- Journal
- ChemMedChem
- Published
- 2025-08-16
- DOI
- https://doi.org/10.1002/cmdc.70019
- Primary Topic
- Botanical Research and Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00