Accelerated Healing of Diabetic and Venous Ulcers with Adjunctive Dehydrated Human Amniotic Membrane: A Real-World Retrospective Cohort Study from a Single-Provider Practice

Aim: To examine whether incorporation of Sanoplast, a dehydrated human acellular amniotic membrane (DHAAM), as a topical adjunct to standard wound dressing improves healing of diabetic and venous ulcers in a real-world setting of a single-physician practice. Results:The area of DHAAM-treated wounds reduced to 60%, 47%, and 34% relative to their original size after the first three applications, respectively.Thus, a 50% reduction in wound area was achieved after two applications of DHAAM, compared to the "Standard of care" (SOC) group, which reached a 50% reduction after seven wound dressing applications.Overall, 69% of wounds treated per protocol with Sanoplast DHAAM completely healed within 12 weeks of treatment compared to 47% in the SOC group.The median closure time for the DHAAM group (9.0 weeks) was less than SOC (13.3 weeks) and the probability of wound closure increased (Hazard Ratio = 1.9; 95% CI: 0.9-4.1).