Reallocation of time between accelerometer-derived movement behaviors, genetic susceptibility, and risk of incident dementia, mortality, and premature death: a longitudinal cohort study
Reallocating time to MVPA from any behavior and substituting physical activity of any intensity for SB were associated with decreased risks of incident dementia, mortality, and premature death, suggesting the significance of maintaining a physically active lifestyle among old adults. Moreover, increasing MVPA level could partially attenuate the strength of association between genetic susceptibility and the risk of dementia.
Authors
- Darui Gao (ORCID: https://orcid.org/0000-0001-7993-0048)
- Yang Pan (ORCID: https://orcid.org/0000-0002-1994-6029)
- Mengmeng Ji (ORCID: https://orcid.org/0000-0002-2859-0087)
- Jie Liang (ORCID: https://orcid.org/0000-0002-3613-8488)
- Wenya Zhang (ORCID: https://orcid.org/0000-0001-9112-7928)
- Yiwen Dai (ORCID: https://orcid.org/0009-0002-2036-4285)
- Yanyu Zhang (ORCID: https://orcid.org/0000-0001-7284-8295)
- Wuxiang Xie (ORCID: https://orcid.org/0000-0001-7527-1022)
- Fanfan Zheng (ORCID: https://orcid.org/0000-0003-2767-2600)
- Jingya Ma
- Yuling Liu
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- Peking Union Medical College Hospital (CN)
- Ministry of Education (RO)
- Peking University First Hospital (CN)
- Beijing Haidian Hospital (CN)
Publication Details
- Journal
- International Journal of Behavioral Nutrition and Physical Activity
- Published
- 2025-08-21
- DOI
- https://doi.org/10.1186/s12966-025-01814-8
- Primary Topic
- Physical Activity and Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Chinese Academy of Medical Sciences