Quantification of neuroinflammation in spinal cord and neuroforamina of patients with painful cervical radiculopathy using [11C]DPA713 PET/CT
These results indicate that a 1T2k model with metabolite corrected image derived input function can be used to describe the kinetics of [<sup>11</sup>C]DPA713 in the spinal cord and neuroforamina in humans. 1T2k <i>V</i> <sub>T</sub> or Logan <i>V</i> <sub>T</sub> can be used as binding metric, while TBR-PP is the recommended choice among simplified models.
Authors
- Meghan A. Koop
- Maqsood Yaqub
- Michaela Coenen (ORCID: https://orcid.org/0000-0001-7492-7907)
- Ronald Boellaard (ORCID: https://orcid.org/0000-0002-0313-5686)
- Michel W. Coppieters (ORCID: https://orcid.org/0000-0002-3958-4408)
- Ivo J. Lutke Schipholt (ORCID: https://orcid.org/0000-0002-6524-7245)
- Elsmarieke van de Giessen
- Bart N.M. van Berckel (ORCID: https://orcid.org/0000-0003-1811-4383)
- G.G.M. Scholten-Peeters (ORCID: https://orcid.org/0000-0002-4409-9554)
- Carmen Vleggeert‐Lankamp (ORCID: https://orcid.org/0000-0001-9597-7225)
- Adriaan A. Lammertsma (ORCID: https://orcid.org/0000-0003-1237-2891)
- Bastiaan C. ter Meulen
- Paul R. Depaauw
Institutions
- Griffith University (AU)
- University Medical Center Groningen (NL)
- Radboud University Nijmegen (NL)
- University of Groningen (NL)
- Leiden University Medical Center (NL)
- Radboud University Medical Center (NL)
- OLVG (NL)
- Amsterdam Neuroscience (NL)
- GGD Amsterdam (NL)
- Elisabeth-TweeSteden Ziekenhuis (NL)
- Gold Coast Health (AU)
- Department of Health (ZA)
- Amsterdam University Medical Centers (NL)
- Health & Safety in Sports (NL)
- Vrije Universiteit Amsterdam (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Frontiers in Nuclear Medicine
- Published
- 2025-08-21
- DOI
- https://doi.org/10.3389/fnume.2025.1569991
- Citations
- 1
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- Amsterdam University Medical Centers