Integrative scRNA-seq and transcriptomic analysis initially reveals monocyte/macrophage activation drives EV-A71-induced immune dysregulation and neural injury in severe HFMD
Macrophages are activated early during EV-A71 infection, thus initiating specific immunity, which is closely related to the severe HFMD. The nerve damage pathway and calcium signaling pathway caused by EV-A71 virus infection of macrophages deserve to more attention.
Authors
- Chenrui Liu (ORCID: https://orcid.org/0009-0003-3393-0394)
- Xiaoli Jia (ORCID: https://orcid.org/0000-0003-4850-4075)
- Shuangsuo Dang (ORCID: https://orcid.org/0000-0002-9257-5711)
- Muqi Wang (ORCID: https://orcid.org/0000-0003-2314-8983)
- Zhang Chu-ting (ORCID: https://orcid.org/0000-0001-6623-4828)
- Meng Zhang (ORCID: https://orcid.org/0000-0002-1800-0928)
- Wen Zhang (ORCID: https://orcid.org/0000-0002-9352-6153)
- Yufeng Zhang (ORCID: https://orcid.org/0000-0001-8702-5291)
- Yaping Li (ORCID: https://orcid.org/0000-0002-0900-5559)
- Huiling Deng (ORCID: https://orcid.org/0009-0003-1850-2690)
- Yu Chen (ORCID: https://orcid.org/0000-0003-3610-594X)
Institutions
- Second Affiliated Hospital of Xi'an Jiaotong University (CN)
- Xi’an Children’s Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-08-21
- DOI
- https://doi.org/10.3389/fimmu.2025.1620633
- Citations
- 2
- Primary Topic
- Viral Infections and Immunology Research
- Type
- article
- Field-Weighted Citation Impact
- 2.78
Funders
- National Natural Science Foundation of China
- Natural Science Basic Research Program of Shaanxi Province