Predictive value of patent foramen ovale diameter for cryptogenic stroke and age-related differences
CS was present in 17.2% of PFO patients. An enlarged diameter of PFO (optimal cut-off value: 1.75 mm in overall and younger; 1.95 mm in elderly) is a crucial anatomical risk factor. Elevated WBC, large RLS, previous stroke/TIA and cortical infarction are also correlated with CS. Age subgroup analysis revealed heterogeneity: PFO anatomy (diameter, RLS) is primary in younger patients, whereas in elderly patients (≥60 years), both PFO anatomy and systemic factors (smoking) should be considered.
Authors
- Min Qiao (ORCID: https://orcid.org/0000-0002-2734-6824)
- Lingcui Meng
- Guanghui Song
- Wei Wang (ORCID: https://orcid.org/0000-0002-3422-0402)
- Rui Wang (ORCID: https://orcid.org/0000-0003-1130-8214)
- Zhenzhen Lin (ORCID: https://orcid.org/0000-0001-8282-3323)
- Lin Yang (ORCID: https://orcid.org/0000-0001-5379-6821)
Institutions
- Guangzhou University of Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2025-08-21
- DOI
- https://doi.org/10.3389/fcvm.2025.1647313
- Primary Topic
- Cardiovascular and Diving-Related Complications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Guangzhou University
- Division of Graduate Education