Genome-wide DNA methylation analysis identifies kidney epigenetic dysregulation in a cystinosis mouse model
These findings underscore the role of epigenetic regulation in the progression of kidney damage in cystinosis and suggest that DNAm could serve as a promising target for novel therapeutic strategies.
Authors
- Marcelo Rossi (ORCID: https://orcid.org/0000-0003-4627-8692)
- Lucia Pedace (ORCID: https://orcid.org/0000-0001-8552-3641)
- Giusi Prencipe (ORCID: https://orcid.org/0000-0003-1152-9041)
- Anna Taranta (ORCID: https://orcid.org/0000-0002-7606-9085)
- Valentina Matteo
- Ester De Leo (ORCID: https://orcid.org/0000-0003-0704-3882)
- Evelina Miele (ORCID: https://orcid.org/0000-0002-4747-1032)
- Marco Tartaglia (ORCID: https://orcid.org/0000-0001-7736-9672)
- Elena Loricchio (ORCID: https://orcid.org/0000-0002-4733-509X)
- Francesco Emma (ORCID: https://orcid.org/0000-0002-0383-3468)
- Andrea Ciolfi (ORCID: https://orcid.org/0000-0002-6191-0978)
- Francesco Bellomo (ORCID: https://orcid.org/0000-0003-2912-8764)
- Ivan Caiello (ORCID: https://orcid.org/0000-0001-8791-6748)
- Fabrizio De Benedetti (ORCID: https://orcid.org/0000-0001-8749-8232)
- Christine Nardini (ORCID: https://orcid.org/0000-0001-7601-321X)
Institutions
- Roma Tre University (IT)
- Bambino Gesù Children's Hospital (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-08-21
- DOI
- https://doi.org/10.3389/fcell.2025.1638123
- Citations
- 3
- Primary Topic
- Biomedical Research and Pathophysiology
- Type
- article
- Field-Weighted Citation Impact
- 4.41
Funders
- Cystinosis Research Foundation