Total ginsenosides enhance γ-globin expression and fetal hemoglobin production in β-thalassemia models
These findings establish TG as a potent, well-tolerated inducer of HbF through transcriptional activation of the γ-globin gene. Its efficacy across erythroid cell lines, primary progenitor cells, and transgenic mouse models underscores its translational potential as a natural therapeutic agent for β-thalassemia.
Authors
- Aiqi Cai (ORCID: https://orcid.org/0000-0001-8381-7208)
- Baosheng Zhu (ORCID: https://orcid.org/0000-0002-5991-1752)
- Yamin Kong
- Yan Guo (ORCID: https://orcid.org/0000-0001-5252-3960)
- Dongling Cai (ORCID: https://orcid.org/0000-0003-4101-2772)
- Guangyu He (ORCID: https://orcid.org/0000-0002-2878-5108)
- Ying Keung Chan (ORCID: https://orcid.org/0000-0002-0148-0064)
Institutions
- Kunming University of Science and Technology (CN)
- Kunming University (CN)
- First People's Hospital of Yunnan Province (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-08-21
- DOI
- https://doi.org/10.3389/fphar.2025.1578237
- Citations
- 1
- Primary Topic
- Hemoglobinopathies and Related Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.63
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- Kunming Institute of Zoology, Chinese Academy of Sciences