Analysis of six CYP450 genetic variants regarding the response to cannabidiol combined with anticonvulsant medication in mexican patients with drug-resistant epilepsy
Treatment with CBD reduced seizures in most patients (68%), which was independent of etiology and seizure type. The genotype <i>CYP3A4</i> *1/rs2242480 may be associated with low response to CBD.
Authors
- Sandra Adela Orozco-Suárez (ORCID: https://orcid.org/0000-0001-5289-8500)
- Iris Angélica Feria-Romero (ORCID: https://orcid.org/0000-0002-8073-2417)
- Consuelo Escamilla-Núñez (ORCID: https://orcid.org/0000-0001-5619-2572)
- Iris E. Martínez‐Juárez (ORCID: https://orcid.org/0000-0001-6512-5312)
- Daniel San‐Juan (ORCID: https://orcid.org/0000-0001-6685-5851)
- Luísa Rocha (ORCID: https://orcid.org/0000-0003-4495-9427)
- Araceli Reyes-Cuayahuitl
Institutions
- Mexican Social Security Institute (MX)
- Centro Medico Nacional Siglo XXI (MX)
- Instituto Nacional de Salud (PE)
- Instituto Nacional de Salud Pública (MX)
- Hospital de Especialidades (MX)
- Instituto Nacional de Neurología y Neurocirugía (MX)
- Instituto Politécnico Nacional (MX)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-08-21
- DOI
- https://doi.org/10.3389/fphar.2025.1626054
- Primary Topic
- Cannabis and Cannabinoid Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Instituto Mexicano del Seguro Social
- Universidad Autónoma del Estado de México
- Fundación IMSS