Model-based prediction of nanoparticle and dissolved form ratios using total concentration data: a case study of SNB-101

This reduced exposure to dissolved SN-38 and irinotecan likely underpins the favorable safety profile observed in dose-escalation studies. This model-based approach underscores the utility of nanoparticle formulations in improving drug delivery and highlights the importance of distinguishing between NP and S forms for accurate efficacy and toxicity predictions. The framework may provide a useful tool for optimizing dose selection and accelerating the clinical development of nanoparticle-based therapeutics.