Elucidating the dynamic tumor microenvironment through deep transcriptomic analysis and therapeutic implication of MRE11 expression patterns in hepatocellular carcinoma
High MRE11 expression is crucial in regulating the immune microenvironment in HCC, fostering immune evasion and driving tumor progression. MRE11 emerges as a promising biomarker for HCC diagnosis and a potential target for personalized immunotherapy.
Authors
- Shaoming Song (ORCID: https://orcid.org/0000-0001-8085-4476)
- Zizheng Wang (ORCID: https://orcid.org/0000-0001-5983-5326)
- Ruiqiu Chen (ORCID: https://orcid.org/0000-0003-1374-3180)
- Chaohui Xiao (ORCID: https://orcid.org/0000-0002-2158-6608)
- Rong Liu (ORCID: https://orcid.org/0000-0001-6123-9152)
- Gong Zhang (ORCID: https://orcid.org/0000-0003-0418-3433)
- Penghui Yang (ORCID: https://orcid.org/0000-0002-4889-9399)
- Lin Zhu (ORCID: https://orcid.org/0000-0001-6072-4623)
- Guineng Zeng
Institutions
- Second Military Medical University (CN)
- Chinese PLA General Hospital (CN)
- Eastern Hepatobiliary Surgery Hospital (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-08-21
- DOI
- https://doi.org/10.1186/s12935-025-03931-7
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Key Research and Development Program of China