Integral approach to organelle profiling in human iPSC-derived cardiomyocytes enhances in vitro cardiac safety classification of known cardiotoxic compounds
Results demonstrate that a combined approach of analyzing morphology and electrophysiology enhances <i>in-vitro</i> prediction and understanding of drug cardiotoxicity. Our integrative approach introduces a potential framework that is accessible, scalable and better aligned with clinical outcomes.
Authors
- Jeroen M. Stein (ORCID: https://orcid.org/0000-0003-1283-016X)
- Anna Savchenko
- Georgios Kosmidis
- Elena Matsa (ORCID: https://orcid.org/0009-0001-3636-2439)
- Tim Meese (ORCID: https://orcid.org/0000-0002-3307-9048)
- Paul G.A. Volders (ORCID: https://orcid.org/0000-0002-2652-1598)
- Thomas Hutschalik (ORCID: https://orcid.org/0009-0009-9667-4811)
- Filip Van Nieuwerburgh (ORCID: https://orcid.org/0000-0001-8815-5485)
- Brigitta Szabó
Institutions
- University College Cork (IE)
- Maastricht University Medical Centre (NL)
- Ghent University (BE)
- Maastricht University (NL)
- Novadip (Belgium) (BE)
- Netherlands Consortium for Healthy Ageing (NL)
- National Institute for Bioprocessing Research and Training (IE)
Publication Details
- Journal
- Frontiers in Toxicology
- Published
- 2025-08-21
- DOI
- https://doi.org/10.3389/ftox.2025.1644119
- Primary Topic
- 3D Printing in Biomedical Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- Horizon 2020