Molecular characterization of HIV-1 near-full-length proviral quasispecies in monocytes from patients across different virological responses
Near-full-length proviral quasispecies amplified from monocytes demonstrated distinct characteristics across virological response groups. Notably, proviral quasispecies in the LLV group exhibited higher genetic diversity, suggesting unique evolutionary dynamics under low-level viral replication. These findings underscore the importance of investigating proviral quasispecies within monocytes to better understand their role in persistent HIV viremia.
Authors
- Linghua Li (ORCID: https://orcid.org/0000-0001-5711-8681)
- Qian Kong (ORCID: https://orcid.org/0000-0002-4776-4898)
- Quanmin Li (ORCID: https://orcid.org/0000-0001-8310-8823)
- Yun Lan
- Weilie Chen
- Yongchun Liang
- Zhilin Zou (ORCID: https://orcid.org/0000-0002-4772-0027)
- Jian Li (ORCID: https://orcid.org/0000-0002-7521-8798)
- Peng Ma (ORCID: https://orcid.org/0000-0003-3947-9146)
- Ruiying He
- Chuyu Zhang
Institutions
- First Affiliated Hospital of Xiamen University (CN)
- Key Laboratory of Guangdong Province (CN)
- Zhongshan Hospital of Xiamen University (CN)
- Guangzhou Eighth People's Hospital (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-08-21
- DOI
- https://doi.org/10.3389/fmicb.2025.1647986
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Key Research and Development Program of China