Integrated neurobehavioral and organ-specific safety profiling of baicalin: acute/subacute toxicity studies
Baicalin showed high acute safety with an LD50 over 4,000 mg/kg in mice, and a subacute no-observed-adverse-effect level (NOAEL) of 2,000 mg/kg, indicating its potential as a neuroprotective agent. However, 4,000 mg/kg doses led to reversible hepatorenal toxicity and biochemical alterations, highlighting the need to monitor organ function during extended high-dose use.
Authors
- Mengyu Chen (ORCID: https://orcid.org/0000-0001-7132-0421)
- Jia Liu (ORCID: https://orcid.org/0000-0003-0383-0934)
- Pei Lin (ORCID: https://orcid.org/0000-0002-9844-945X)
- Ye Lu (ORCID: https://orcid.org/0009-0009-4948-9680)
- Jiali Yang (ORCID: https://orcid.org/0000-0001-8070-8751)
- Jing Zhao (ORCID: https://orcid.org/0000-0003-0764-8179)
- Zhang Wan (ORCID: https://orcid.org/0000-0003-0879-0230)
- Pei He
- Ping Xin
Institutions
- Hebei Medical University (CN)
- Fourth Hospital of Hebei Medical University (CN)
- Hebei University of Chinese Medicine (CN)
- Affiliated Hospital of Hebei University (CN)
- Hebei Academy of Sciences (CN)
- First Affiliated Hospital of Hebei Medical University (CN)
- Renmin University of China (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-08-21
- DOI
- https://doi.org/10.3389/fphar.2025.1607919
- Primary Topic
- Flavonoids in Medical Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- State Administration of Traditional Chinese Medicine of the People's Republic of China
- Hebei Province Graduate Innovation Funding Project