Gypenoside XLIX inhibiting PI3K/AKT/FOXO1 signaling pathway mediated neuronal mitochondrial autophagy to improve patients with ischemic stroke
Gypenoside XLIX alleviates ischemic stroke injury by activating the PI3K/AKT/FOXO1 pathway, enhancing mitochondrial autophagy, and reducing oxidative stress, supporting its potential as a novel neuroprotective agent in stroke management.
Authors
- Changyun Liu (ORCID: https://orcid.org/0000-0003-1683-5101)
- Lin Yang (ORCID: https://orcid.org/0000-0002-7576-4481)
- Xi Rong (ORCID: https://orcid.org/0000-0001-7234-3801)
- Zhenwei Zhao (ORCID: https://orcid.org/0000-0001-8940-202X)
- Yonglei Liu (ORCID: https://orcid.org/0000-0003-0976-3859)
- Hongdie Mao
- Hui Cai (ORCID: https://orcid.org/0000-0002-6001-0513)
- Xiaoling Yin
- Jishuai Zhao
- Zhengguang Sha
Institutions
- Fujian Medical University (CN)
- Union Hospital (CN)
- Dali University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-08-21
- DOI
- https://doi.org/10.3389/fphar.2025.1600435
- Citations
- 1
- Primary Topic
- Ginseng Biological Effects and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.81