The endoplasmic reticulum stress-ferroptosis reciprocal signaling orchestrates anti-tumor effect of anlotinib in anaplastic thyroid cancer
Anlotinib showed superior efficacy in treating ATC compared to lenvatinib, independent of their anti-angiogenic properties. The ability of anlotinib to induce ER stress-mediated ferroptosis suggests that targeting ferroptosis may hold promise as a therapeutic strategy for ATC.
Authors
- Zhuo Tan
- Juyong Liang (ORCID: https://orcid.org/0000-0003-0063-3847)
- Liehao Jiang
- Wei Teng (ORCID: https://orcid.org/0000-0001-5663-1440)
- Jiajun Wu (ORCID: https://orcid.org/0009-0002-8378-1764)
- Yehao Guo
- Jiafeng Wang (ORCID: https://orcid.org/0000-0002-2360-5032)
- Ding Lingling
Institutions
- Hangzhou Normal University (CN)
- Wenzhou Medical University (CN)
- Zhejiang Cancer Hospital (CN)
- Zhejiang Provincial People's Hospital (CN)
- Hangzhou Medical College (CN)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-08-21
- DOI
- https://doi.org/10.1186/s12935-025-03947-z
- Citations
- 6
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 9.11
Funders
- Health Commission of Guizhou Province
- National Natural Science Foundation of China
- Natural Science Foundation of Zhejiang Province