2′-Fucosyllactose mitigates cognitive deficits in Alzheimer models: targeting amyloid pathology, oxidative stress, and synaptic plasticity
2'-FL improved cognitive performance in 5xFAD mice, reduced Aβ plaque deposition and pro-inflammatory cytokine levels <i>in vivo</i>, and mitigated oxidative stress and synaptic dysfunction in cellular models. These findings indicate that 2'-FL modulates multiple pathological features relevant to AD in preclinical models.
Authors
- In‐Jun Yang (ORCID: https://orcid.org/0000-0002-6113-1325)
- Tae Woo Oh (ORCID: https://orcid.org/0000-0001-7184-6503)
- Jong-Won Yoon (ORCID: https://orcid.org/0000-0002-6972-0984)
- Yeasmin Akter Munni (ORCID: https://orcid.org/0000-0001-5232-7214)
- Sang Il Gum (ORCID: https://orcid.org/0000-0002-9395-5011)
- Young‐Ha Song (ORCID: https://orcid.org/0000-0002-9650-7011)
- Seon-min Jeon
- Khoa Nguyen Tran (ORCID: https://orcid.org/0000-0002-1220-9616)
- Meeyul Hwang
Institutions
- Dongguk University (KR)
- Korea Institute of Oriental Medicine (KR)
- Theragen (KR)
- Protein Technologies (United Kingdom) (GB)
- Institute of Aging (CA)
- Korea University of Science and Technology (KR)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-08-21
- DOI
- https://doi.org/10.3389/fphar.2025.1598030
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Dongguk University
- Korea Institute of Oriental Medicine