Brief transcranial focused ultrasound stimulation causes lasting modifications to the synaptic circuitry of the hippocampus
The results indicate that tFUS can fundamentally modulate key signalling mechanisms that are responsible for determining the synaptic efficacy in a neural circuit. Importantly, these effects last beyond the duration of the stimulus. These findings provide a mechanistic insight into the sustained impact of tFUS on network function, and emphasise the importance of considering such effects in animal and human studies.
Authors
- Daniel J. Whitcomb (ORCID: https://orcid.org/0000-0003-2703-1643)
- Tom G. J. Steward (ORCID: https://orcid.org/0000-0002-7515-1706)
- Jianping Jiang (ORCID: https://orcid.org/0000-0002-4689-3399)
- Benjamin Clennell (ORCID: https://orcid.org/0000-0001-6869-289X)
- Kwangwook Cho (ORCID: https://orcid.org/0000-0001-6724-7073)
- Bruce W. Drinkwater (ORCID: https://orcid.org/0000-0002-8307-1175)
- Kate J. Heesom (ORCID: https://orcid.org/0000-0002-5418-5392)
- Alanood I. Alqahtani (ORCID: https://orcid.org/0009-0006-0801-6295)
- Elek Molnár (ORCID: https://orcid.org/0000-0002-3525-4671)
- W. E. Watts
- John L. Crompton
- Anna Andrieu
- Igino Rafael Besinga
- Konoha Izaki-Lee
- Abhishek Binodh
- Robyn Cuthell
- Deniz Tonyali
- Rosie Taaffe
Institutions
- King's College London (GB)
- University of Bristol (GB)
- UK Dementia Research Institute (GB)
Publication Details
- Journal
- Brain stimulation
- Published
- 2025-08-21
- DOI
- https://doi.org/10.1016/j.brs.2025.08.014
- Citations
- 3
- Primary Topic
- Ultrasound and Hyperthermia Applications
- Type
- article
- Field-Weighted Citation Impact
- 2.02
Funders
- BRACE
- UK Research and Innovation
- Medical Research Council
- Innovate UK