GLP-1R signaling does not modify the severity of experimental graft versus host disease
Although gut T cells express a functional GLP-1R, GLP-1R signaling has no meaningful impact on systemic or intestinal inflammation or microbiota composition in mice with experimental aGvHD, highlighting that the anti-inflammatory actions of GLP-1 medicines are highly context-dependent.
Authors
- K.W. Annie Bang (ORCID: https://orcid.org/0009-0000-5506-0543)
- Bernardo Yusta
- Chi Kin Wong (ORCID: https://orcid.org/0000-0003-4828-8413)
- Daniel J. Drucker (ORCID: https://orcid.org/0000-0001-6688-8127)
- Dianne Matthews
- Laurie L. Baggio
- Jacqueline A. Koehler
Institutions
- Lunenfeld-Tanenbaum Research Institute (CA)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2025-08-21
- DOI
- https://doi.org/10.1016/j.molmet.2025.102235
- Citations
- 3
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 6.02
Funders
- Canadian Institutes of Health Research