Prognostic Value of Multicolor-Flow Cytometric Measurable Residual Disease Detection in Acute Myeloid Leukemia Prior to Allogeneic Hematopoietic Cell Transplantation: Potential Role of HLA-DR
We implemented a standardized multicolor-flow cytometry approach to monitor MRD in AML patients undergoing alloHCT. MRD positivity predicted inferior OS and RFS, surpassing cytomorphology. Notably, HLA-DR expression on residual leukemic cells was associated with favorable outcomes, highlighting the role of immunogenicity. Comprehensive MRD assessment may enable personalized post-transplant strategies.
Authors
- Johannes Schetelig (ORCID: https://orcid.org/0000-0002-2780-2981)
- Michael Krämer (ORCID: https://orcid.org/0000-0002-0251-2726)
- Uta Oelschlägel
- Christoph Röllig (ORCID: https://orcid.org/0000-0002-3791-0548)
- Martin Bornhäuser (ORCID: https://orcid.org/0000-0002-5916-3029)
- Ingmar Glauche (ORCID: https://orcid.org/0000-0002-2524-1199)
- Jonas Schadt (ORCID: https://orcid.org/0000-0002-2687-9178)
- Maximilian Alexander Röhnert (ORCID: https://orcid.org/0000-0001-8213-2047)
- Jan Moritz Middeke (ORCID: https://orcid.org/0000-0003-3250-293X)
- Friedrich Stölzel (ORCID: https://orcid.org/0000-0003-0653-5332)
- Desireé Kunadt (ORCID: https://orcid.org/0000-0001-8750-5308)
- Christian Löffler (ORCID: https://orcid.org/0000-0001-9401-3811)
- Friedemann Uschner (ORCID: https://orcid.org/0000-0002-1191-9448)
- Lars Thielecke
- Malte von Bonin (ORCID: https://orcid.org/0000-0002-2995-3230)
- Christian Thiede
Institutions
- University Hospital Carl Gustav Carus (DE)
Publication Details
- Journal
- Clinical Lymphoma Myeloma & Leukemia
- Published
- 2025-08-21
- DOI
- https://doi.org/10.1016/j.clml.2025.08.013
- Citations
- 1
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 1.77
Funders
- Deutsche Forschungsgemeinschaft
- Technische Universität Dresden