Quercetin improves myocardial ischemia–reperfusion injury by regulating macrophage M2 polarization through Bcl-2/Beclin-1 complex
This study provides the first evidence that quercetin exerts cardioprotective effects in MIRI by promoting M2 macrophage polarization. Furthermore, it elucidates a novel molecular mechanism in which quercetin regulates autophagy to drive M2 polarization, offering experimental support for quercetin as a potential therapeutic strategy for MIRI.
Authors
- Wuming Hu (ORCID: https://orcid.org/0000-0003-3257-6699)
- Lingchun Lv
- Sailing Hu
- Jiayi Shen (ORCID: https://orcid.org/0000-0001-5604-7973)
Institutions
- Lishui Central Hospital (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-08-21
- DOI
- https://doi.org/10.1186/s40001-025-03077-2
- Citations
- 3
- Primary Topic
- Cardiac Ischemia and Reperfusion
- Type
- article
- Field-Weighted Citation Impact
- 4.41
Funders
- Natural Science Foundation of Zhejiang Province