Prkci activates Jak2/Stat3 signaling to promote tumor angiogenesis
These findings identify Prkci as a key regulator of angiogenesis in CRC through Jak2/Stat3 signaling activation. Targeting Prkci could provide a novel therapeutic approach to inhibit tumor angiogenesis and limit CRC progression.
Authors
- Guangshi Liu
- Wenbin Zhang (ORCID: https://orcid.org/0000-0002-1024-6165)
- Peng Li (ORCID: https://orcid.org/0000-0002-9026-9999)
- Tao Li (ORCID: https://orcid.org/0000-0002-9724-3812)
- Xinhui Yang
Institutions
- Xinjiang Medical University (CN)
- Tumor Hospital of Xinjiang Medical University (CN)
- People's Hospital of Xinjiang Uygur Autonomous Region (CN)
Publication Details
- Journal
- Neoplasia
- Published
- 2025-08-21
- DOI
- https://doi.org/10.1016/j.neo.2025.101219
- Primary Topic
- Cytokine Signaling Pathways and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00