Glutaminase inhibition ameliorates cancer-associated fibroblast lipid support of pancreatic cancer cell growth
Our findings emphasize the importance of glutamine metabolism inhibition in suppressing tumor growth and disrupting CAF-mediated crosstalk. We further underscore the potential of glutamine antagonist prodrugs as a strategy to target metabolic vulnerabilities in PDAC.
Authors
- Nicholas P. Lesner (ORCID: https://orcid.org/0000-0001-9734-8828)
- Xu Han (ORCID: https://orcid.org/0000-0002-9317-774X)
- M. Celeste Simon (ORCID: https://orcid.org/0000-0001-7213-9499)
- Tran Ngoc Van Le (ORCID: https://orcid.org/0000-0002-0342-2634)
- Laura C. Kim (ORCID: https://orcid.org/0000-0001-8229-2745)
- Xuanyan Cai
Institutions
- Children's Hospital of Philadelphia (US)
- Cancer Research Institute (US)
- UPMC Hillman Cancer Center (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Cancer & Metabolism
- Published
- 2025-08-20
- DOI
- https://doi.org/10.1186/s40170-025-00389-z
- Citations
- 1
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Damon Runyon Cancer Research Foundation
- University of Pennsylvania
- National Cancer Institute