The Effect of Artificial Oocyte Activation on Blastocyst Development in Patients With Low Blastocyst Rates: A Retrospective Cohort Study

The literature still lacks strong evidence for AOA overcoming impaired embryonic development. Therefore, AOA remains reserved for couples with a failed or low fertilization history to improve fertilization results. Optimal laboratory conditions and ovarian stimulation modifications without AOA may improve blastocyst rates. Further research is needed to validate our findings due to the presence of confounding factors, small sample size, and retrospective design of the study.