Evaluation of Serum Complement Components in Pediatric IgA Vasculitis: A Case-Control Study
The data suggest that lower CFH levels may signal systemic dysregulation of the alternative pathway in IgAV. In contrast, the serum levels of sC5b-9, MBL, and MASP-1 appear inadequate as markers for predicting renal involvement. Further research with larger cohorts that includes genetic analyses and examination of kidney tissue is needed to better define the contribution of complement activation in IgAV-related nephritis.
Authors
- Gülden Hakverdi (ORCID: https://orcid.org/0000-0002-8078-0451)
- Güzide Aksu (ORCID: https://orcid.org/0000-0003-2714-0903)
- Burçe Emine Dörtkardeşler (ORCID: https://orcid.org/0000-0002-6212-9286)
- Sait Şen (ORCID: https://orcid.org/0000-0002-1100-6657)
- Raziye Burcu Taşkın (ORCID: https://orcid.org/0000-0003-1734-8102)
- Seçil Conkar Tunçay (ORCID: https://orcid.org/0000-0002-2491-9914)
Institutions
- Sivas Cumhuriyet Üniversitesi (TR)
- Izmir University (TR)
- Ege University (TR)
- Sağlık Bilimleri Üniversitesi (TR)
- Izmir Tepecik Eğitim ve Araştırma Hastanesi (TR)
Publication Details
- Journal
- Children
- Published
- 2025-08-20
- DOI
- https://doi.org/10.3390/children12081090
- Citations
- 2
- Primary Topic
- Complement system in diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.59
Funders
- Ege Üniversitesi