Virtual reality navigation for the early detection of Alzheimer’s disease
These findings suggest that PI quantified by 3D VR navigation systems may be useful as a surrogate diagnostic tool for the detection of early AD pathophysiology. The hierarchical application of 3D VR PI and plasma p-tau181, in particular, may be an effective combinatorial biomarker for early AD neurodegeneration. These findings advance the application of non-invasive diagnostic tools for early testing and monitoring of AD, paving the way for timely therapeutic interventions and improved epidemiological patient outcomes.
Authors
- Hirohisa Watanabe (ORCID: https://orcid.org/0000-0001-8553-8536)
- Atsushi Kasai (ORCID: https://orcid.org/0000-0002-1612-3078)
- Reiko Ohdake (ORCID: https://orcid.org/0000-0001-8282-9434)
- Mizuki Ito (ORCID: https://orcid.org/0000-0003-4470-1004)
- Shinsuke Ishigaki (ORCID: https://orcid.org/0000-0002-9555-0659)
- Hiroshi Toyama (ORCID: https://orcid.org/0000-0002-5341-1693)
- Riki Koike
- Sayuri Shima (ORCID: https://orcid.org/0000-0003-1761-0123)
- Junichiro Yoshimoto (ORCID: https://orcid.org/0000-0001-7995-0321)
- Harutsugu Tatebe
- Yasuaki Mizutani (ORCID: https://orcid.org/0000-0002-5709-8526)
- Epifanio Bagarinao (ORCID: https://orcid.org/0000-0001-5000-6943)
- Kazuya Kawabata (ORCID: https://orcid.org/0000-0002-8851-4377)
- Akihiro Ueda (ORCID: https://orcid.org/0000-0002-9636-3011)
- Takahiko Tokuda (ORCID: https://orcid.org/0000-0002-7411-4911)
- Akihiko Takashima
- Hata Jun'ichi
Institutions
- Fujita Health University (JP)
- Shiga University of Medical Science (JP)
- Shiga University (JP)
- National Institutes for Quantum Science and Technology (JP)
- Medical innovation (France) (FR)
- Gakushuin University (JP)
- Nagoya University (JP)
- Tokyo Metropolitan University (JP)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-08-20
- DOI
- https://doi.org/10.3389/fnagi.2025.1571429
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Agency for Medical Research and Development
- Fujita Health University