Prepandemic levels of cytokines and immunoglobulins and risk of SARS-CoV-2 infection and COVID-19 in the general population of Barcelona
The unique longitudinal design of this study, with measurements before and during the pandemic in a general population, provides novel knowledge on the protective and detrimental effects of specific individual cytokines and immunoglobulins, and their mixtures, on the risk of SARS-CoV-2 seropositivity and COVID-19. If confirmed, findings would be significantly relevant for medicine and public health.
Authors
- Miguel Ángel Muñoz (ORCID: https://orcid.org/0000-0002-4083-3248)
- David Prieto‐Merino (ORCID: https://orcid.org/0000-0001-5001-0061)
- Marta Vidal (ORCID: https://orcid.org/0000-0001-6891-7032)
- Cristina Rius
- José Pumarega (ORCID: https://orcid.org/0000-0001-6950-6702)
- L Campi (ORCID: https://orcid.org/0009-0002-1030-9135)
- Alfons Jiménez (ORCID: https://orcid.org/0000-0003-0301-3344)
- Gemma Moncunill (ORCID: https://orcid.org/0000-0001-5105-9836)
- Leonardo Trasande (ORCID: https://orcid.org/0000-0002-1928-597X)
- Francisco Bolúmar (ORCID: https://orcid.org/0000-0001-8007-3231)
- Ruth Aguilar (ORCID: https://orcid.org/0000-0003-3277-3107)
- Miquel Porta (ORCID: https://orcid.org/0000-0003-1684-7428)
- Magda Gasull (ORCID: https://orcid.org/0000-0003-4546-3650)
- Antonio Peña‐Fernández (ORCID: https://orcid.org/0000-0002-5690-5445)
- Carlota Dobaño (ORCID: https://orcid.org/0000-0002-6751-4060)
- Judit Villar-García (ORCID: https://orcid.org/0000-0003-2813-8426)
Institutions
- University of North Carolina at Chapel Hill (US)
- Universitat Autònoma de Barcelona (ES)
- Universitat Pompeu Fabra (ES)
- City University of New York (US)
- Universidad de Alcalá (ES)
- Centro de Investigación en Red en Enfermedades Cardiovasculares (ES)
- Departament de Salut (ES)
- Agència de Salut Pública de Catalunya (ES)
- Institut Universitari d'Investigació en Atenció Primària Jordi Gol (ES)
- Barcelona Institute for Global Health (ES)
- Institut Català de la Salut (ES)
- Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (ES)
- Wagner College (US)
- New York University (US)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- Frontiers in Public Health
- Published
- 2025-08-20
- DOI
- https://doi.org/10.3389/fpubh.2025.1548456
- Primary Topic
- COVID-19 Clinical Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Centres de Recerca de Catalunya
- European Commission
- Generalitat de Catalunya
- Universitat Autònoma de Barcelona
- Instituto de Salud Carlos III
- Agencia Estatal de Investigación
- European Social Fund