The association of maternal and infant early gut microbiota with respiratory infections in infants
The maternal and early-life infant gut microbiota profile was associated with infants' respiratory tract infections within the first 6 months of life. In infants, the higher abundance of adult-type butyrate producers and some Enterobacteriaceae were associated with respiratory tract infections, while mothers' microbiota was significantly enriched with Enterococcus, Citrobacter, and Enterobacter spp. in the group of infants with infections. The results indicate that maternal and infant gut microbiota may play a role in predisposing an infant to infections during early life. Further studies are warranted on how this link is mediated.
Authors
- Aki Saarikivi
- Jani Mälkönen
- Kaija‐Leena Kolho (ORCID: https://orcid.org/0000-0001-9170-8415)
- Willem M. de Vos (ORCID: https://orcid.org/0000-0002-0273-3166)
- Katri Korpela (ORCID: https://orcid.org/0000-0001-5031-2713)
- Anne Salonen (ORCID: https://orcid.org/0000-0002-6960-7447)
- Terhi Solasaari (ORCID: https://orcid.org/0009-0004-7242-4790)
- Sanni Hyvönen
- Terhi Ruuska-Loewald
Institutions
- University of Helsinki (FI)
- Oulu University Hospital (FI)
- Helsinki University Hospital (FI)
- Helsinki Children's Hospital (FI)
- Tampere University Hospital (FI)
- Tampere University (FI)
- Hospital District of Helsinki and Uusimaa (FI)
- City of Helsinki (FI)
- Wageningen University & Research (NL)
- University of Oulu (FI)
Publication Details
- Journal
- Pediatric Research
- Published
- 2025-08-20
- DOI
- https://doi.org/10.1038/s41390-025-04326-0
- Citations
- 2
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Helsingin Yliopisto
- Helsingin ja Uudenmaan Sairaanhoitopiiri
- Suomen Lääketieteen Säätiö
- Tekes
- Juho Vainion Säätiö
- Signe ja Ane Gyllenbergin Säätiö
- Lastentautien Tutkimussäätiö
- Business Finland