Risk of disease progression in first-line metastatic colorectal cancer therapy to guide disease reassessments―analysis of 11 trials by AIO and GONO
The distribution of PD events does not follow a Gaussian pattern, with the highest density observed between the third and fourth reassessment of a bimonthly surveillance schedule. In clearly unresectable patients, restaging should focus on the interval between 6 and 10 months and not on the initiation of systemic therapy. Our model might be helpful to schedule radiological reassessments according to baseline characteristics, early response and the expected duration of each treatment efficacy.
Authors
- Martin Fuchs (ORCID: https://orcid.org/0000-0003-4824-2511)
- V. Heinemann
- Lena Weiss (ORCID: https://orcid.org/0000-0002-8101-3529)
- S. Stintzing
- Arndt Stahler (ORCID: https://orcid.org/0000-0003-1041-0137)
- C. Antoniotti
- Thomas Decker (ORCID: https://orcid.org/0000-0003-3814-8775)
- Paolo Frumento (ORCID: https://orcid.org/0000-0002-4209-2586)
- S. Lonardi
- Gabriele Masi (ORCID: https://orcid.org/0000-0001-7770-926X)
- F. Bergamo
- Dominik Paul Modest (ORCID: https://orcid.org/0000-0002-6853-0599)
- Federica Morano (ORCID: https://orcid.org/0000-0002-5306-3596)
- Davide Rossini (ORCID: https://orcid.org/0000-0002-9222-1913)
- Kathrin Heinrich (ORCID: https://orcid.org/0000-0003-3580-2313)
- Florian Kaiser (ORCID: https://orcid.org/0000-0002-5844-1779)
- L. Salvatore
- F. Pietrantonio
- C. Cremolini
- Ludwig Fischer von Weikersthal (ORCID: https://orcid.org/0000-0002-9128-0807)
- M M Germani
Institutions
- University of Pisa (IT)
- University of Applied Sciences Landshut (DE)
- München Klinik Bogenhausen (DE)
- Istituto Oncologico Veneto (IT)
- MVZ Labor Ravensburg (DE)
- Klinikum St. Marien Amberg (DE)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- University of Florence (IT)
- Charité - Universitätsmedizin Berlin (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Annals of Oncology
- Published
- 2025-08-20
- DOI
- https://doi.org/10.1016/j.annonc.2025.08.001
- Citations
- 4
- Primary Topic
- Colorectal Cancer Treatments and Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.18
Funders
- European Commission