Piezo1: a key regulator in intestinal mechanosensation and inflammatory modulation
Recently, Piezo1's function in the intestine was explored by Xie et al. This manuscript highlights their findings that Piezo1+ cholinergic excitatory neurons are key mechanosensors for detecting intestinal pressure and maintaining normal gut motility and inflammatory homeostasis, and outlooks the potential clinical application of this discovery.
Authors
- Haihong Jiang (ORCID: https://orcid.org/0000-0002-0116-052X)
- Chen Zhang (ORCID: https://orcid.org/0000-0002-5733-7574)
- Yanlan Yu (ORCID: https://orcid.org/0000-0003-1351-7896)
- Yifeng Luo (ORCID: https://orcid.org/0000-0001-8528-0942)
Institutions
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Sir Run Run Shaw Hospital (CN)
Publication Details
- Journal
- Medicine Plus
- Published
- 2025-08-20
- DOI
- https://doi.org/10.1016/j.medp.2025.100095
- Primary Topic
- Erythrocyte Function and Pathophysiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00