Discovery of insect Blaps rhynchopetera Fairmaire extracts with anti-tyrosinase activity and anti-melanin deposition
In this study, we identified the primary whitening active ingredients of <i>B. rhynchopetera Fairmaire</i> and utilized network pharmacology and molecular dynamics simulation to investigate the mechanism underlying the whitening effect of EBR. This work reveals that insect extraction may have broad application prospects in the preparation of cosmetics. To our knowledge, this is the first report identifying the flavonoids quercetin, luteolin, myricetin, and apigenin as whitening-active components in insects.
Authors
- Kaixun Cao
- James Mwangi (ORCID: https://orcid.org/0000-0002-5467-9675)
- Xi Yang (ORCID: https://orcid.org/0000-0003-0689-1417)
- Lei Shi (ORCID: https://orcid.org/0000-0001-9100-897X)
- Chengye Wang (ORCID: https://orcid.org/0000-0002-6184-9863)
- Min Zhao (ORCID: https://orcid.org/0000-0001-5498-3434)
- Chengchen Zhang (ORCID: https://orcid.org/0000-0001-8802-539X)
- Yifan Chen (ORCID: https://orcid.org/0000-0002-9054-3089)
- Haoyang Zhang (ORCID: https://orcid.org/0000-0002-7274-336X)
- Qiumin Lu (ORCID: https://orcid.org/0000-0001-9986-9950)
- Shengwen Zhou
Institutions
- Nanjing Agricultural University (CN)
- Kunming Institute of Zoology (CN)
- Research Institute of Resource Insects (CN)
- University of Chinese Academy of Sciences (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-08-20
- DOI
- https://doi.org/10.3389/fphar.2025.1595534
- Primary Topic
- melanin and skin pigmentation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Kunming Institute of Zoology, Chinese Academy of Sciences