Interactions between gut microbiota, plasma metabolome and brain function in the setting of a HIV cure trial
While the direct effect of the intervention on the observed shifts cannot be conclusively determined in this study settings, these findings strengthen the link between gut bacteria, related metabolites, and neurocognitive function in PWH, and provide an analytical framework for future validation studies aimed at discovering predictive biomarkers for neurocognitive impairment in PWH.
Authors
- José Moltó (ORCID: https://orcid.org/0000-0003-4564-1963)
- Bonaventura Clotet (ORCID: https://orcid.org/0000-0003-3232-4598)
- Anna Prats (ORCID: https://orcid.org/0000-0002-3586-4525)
- Ashish Sharma (ORCID: https://orcid.org/0000-0001-9444-7046)
- Rafick‐Pierre Sékaly (ORCID: https://orcid.org/0000-0002-7816-4828)
- Beatriz Mothe (ORCID: https://orcid.org/0000-0001-9975-407X)
- Carles Soriano‐Mas (ORCID: https://orcid.org/0000-0003-4574-6597)
- Alessandra Borgognone (ORCID: https://orcid.org/0000-0001-5487-3016)
- José A. Muñoz-Moreno (ORCID: https://orcid.org/0000-0002-7239-5422)
- Ignacio Martínez‐Zalacaín (ORCID: https://orcid.org/0000-0002-4036-0284)
- Christian Brander (ORCID: https://orcid.org/0000-0002-0548-5778)
- Roger Paredes
Institutions
- Universitat de Vic - Universitat Central de Catalunya (ES)
- Institució Catalana de Recerca i Estudis Avançats (ES)
- Universitat Oberta de Catalunya (ES)
- Emory University (US)
- Instituto de Salud Carlos III (ES)
- Bellvitge University Hospital (ES)
- IrsiCaixa (ES)
- Institut d'Investigació Biomédica de Bellvitge (ES)
- Centro de Investigación Biomédica en Red de Salud Mental (ES)
- Centro de Investigación Biomédica en Red (ES)
- Fundació ACE (ES)
- Center for Global Health (US)
- Hospital Universitari Germans Trias i Pujol (ES)
- Case Western Reserve University (US)
- Universitat de Barcelona (ES)
- Universitat Politècnica de Catalunya (ES)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-08-20
- DOI
- https://doi.org/10.3389/fcimb.2025.1629901
- Citations
- 1
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Styrelsen för Internationellt Utvecklingssamarbete
- European Commission
- Instituto de Salud Carlos III
- European Regional Development Fund